Assenagon Asset Management S.A. 13F: Adds $227M to ISRG Stake

Assenagon Asset Management grew its investment in Intuitive Surgical, Inc. (NasdaqGS: ISRG) during the recent quarter, according to a Form 13F filing with the SEC on October 15, 2026. Because 13F reports look backward, these numbers show positions held at the end of the reporting period and might not reflect the fund's current holdings.

Inside Assenagon Asset Management's Intuitive Surgical Trade

The firm boosted its position by picking up an additional 558,099 shares of the medical technology maker. That marks a 55.8% increase from its previous holding of 999,841 shares. Assenagon ended the period with a total of 1,557,940 shares valued at approximately $633.5 million.

Other Institutional Activity in Intuitive Surgical

Other large money managers adjusted their stakes in Intuitive Surgical around the same time. Blackrock Inc. trimmed its holdings by 0.2%, dropping 51,129 shares to end with 30,024,648 shares worth about $12.8 billion. Vanguard Capital Management LLC grew its holdings by 0.2%, adding 50,777 shares to finish with 23,131,099 shares valued at roughly $9.8 billion. State Street Corporation lifted its stake by 1.4%, picking up 215,526 shares to hold 16,063,040 shares worth about $6.8 billion. Invesco Ltd. increased its holdings by 5.8%, adding 653,500 shares to end with 11,843,563 shares worth about $5.0 billion. Meanwhile, Price (T.Rowe) Associates Inc reduced its position by 10.1%, dropping 1,263,250 shares to hold 11,256,570 shares worth about $4.8 billion.

Intuitive Surgical, Inc. Stock Up 1.7%

Intuitive Surgical shares recently traded around $427.42 as of October 16, 2026. The stock sits about 29.2% below its 52-week high of $603.88 and roughly 30.1% above its 52-week low of $328.57. It trades about 9.4% above its 50-day moving average of $390.61 and 2.9% below its 200-day moving average of $440.36. The company carries a trailing price-to-earnings ratio of 49.1.

Recent Earnings

For its trailing twelve months, Intuitive Surgical reported $11.0 billion in revenue and earnings of $8.72 per share. The company posted a net profit margin of 28.4% and a return on equity of 17.4%, with year-over-year revenue growth of 18.5%. The company's next earnings report is scheduled for October 20, 2026.

Insider Buying and Selling at Intuitive Surgical, Inc.

Company insiders also made trades during the months leading up to the filing. Officer Mark Preston Brosius sold 154 shares on August 21, 2026, for a total value of $59,439. Brosius later sold 69 shares on September 9, 2026, worth $24,671, and another 48 shares on September 11, 2026, worth $17,141. Additionally, officer Fredrik Widman sold 1,089 shares at an average price of $374.44 on September 15, 2026, for a total of $407,765. None of these transactions were reported as part of a pre-arranged Rule 10b5-1 trading plan.

Analysts Set New Price Targets

Wall Street analysts have updated their outlooks on Intuitive Surgical in recent months. On July 30, 2026, HSBC downgraded the stock to a Hold rating with a $931 price target. Oppenheimer upgraded the stock to an Outperform rating with a $500 target on August 12, 2026. BTIG reiterated its Buy rating on September 8, 2026, setting a $469 price target, and later maintained its Buy rating on October 12, 2026, while adjusting its target to $454. Barclays initiated coverage on October 7, 2026, with an Overweight rating and a $485 price target. The stock currently holds a consensus recommendation of Buy, with a mean price target of $478.53 across 30 analyst opinions.

About Intuitive Surgical

Headquartered in Sunnyvale, California, Intuitive Surgical develops and markets robotic-assisted systems and instruments that help healthcare providers perform minimally invasive surgeries. Its flagship products are widely used in hospitals around the world. Institutional interest remains strong as the company prepares for its upcoming earnings release.

Bottom Line

Assenagon Asset Management's sizable purchase underscores ongoing institutional interest in the medical device maker. Investors will be watching closely when Intuitive Surgical reports its next financial results on October 20, 2026. Keep in mind that 13F filings reflect past holdings and may not capture current trading activity. Keep in mind that 13F filings are backward-looking: they show holdings as of the end of the reporting quarter and may not represent the fund's current position.