Barclays Raises Intuitive Surgical (ISRG) Price Target to $500

Intuitive Surgical, Inc. (ISRG) business photo

Key Points

  • Barclays maintained an Overweight rating on Intuitive Surgical, Inc. on October 21, 2026, and lifted its price target to $500.00 from $485.00.
  • Barclays's $500 price target implies 17.73% upside from Intuitive Surgical, Inc.'s ($ISRG) current $424.71 share price.
  • The medical device maker recently reported trailing twelve month revenue of $11.03 billion alongside strong profit margins and double-digit revenue growth.
  • Wall Street maintains a general buy consensus on the stock, with 30 analyst opinions guiding a mean price target of $478.53.

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On October 21, 2026, Barclays maintained its Overweight rating on Intuitive Surgical, Inc. (NasdaqGS: ISRG) while raising its price target to $500.00 from $485.00. The research note arrived as Wall Street firms updated their views on the medical device maker following recent financial figures. Shares of Intuitive Surgical closed at $438.00 on October 20, 2026, and recently traded around $424.71, putting them down about 3.0% since that close.

ISRG Intuitive Surgical, Inc.
$438 -22.06% year to date
Daily close · Oct 20, 2026
Analyst rating track record

Barclays vs. the S&P 500

YTD return +1.95% hypothetical
All-time return +1.95% S&P 500 +1.40%
vs. S&P 500 +0.55% ahead of the index

Hypothetical returns from Barclays's disclosed trades, not real profit or advice. How we model this.

Barclays's Call on Intuitive Surgical

In its October 21, 2026 note, Barclays kept an Overweight rating on the shares and bumped up its target price to $500.00 from $485.00. Other firms also weighed in on the same day. Evercore ISI Group maintained an In-Line rating with a target of $385.00, down from $400.00. Wells Fargo kept an Overweight rating and trimmed its target from $487.00 to $486.00. TD Cowen reiterated a Buy rating with an unchanged target of $485.00. RBC Capital maintained an Outperform rating while lowering its target from $575.00 to $550.00.

Intuitive Surgical, Inc. Stock Down 0.5%

The stock recently changed hands around $424.71 as of October 21, 2026, sitting below its 200-day moving average of $438.97 but above its 50-day moving average of $392.76. The company carries a market capitalization of roughly $153.03 billion and a P/E ratio of 48.95 based on recent earnings.

12-month forecast

$ISRG price target

Intuitive Surgical, Inc. daily closes and this analyst's $500 target. Not advice.

Recent Earnings

Intuitive Surgical reported trailing twelve month revenue of $11.03 billion with trailing earnings per share of $8.85. The company posted a year-over-year revenue growth rate of 18.5%, supported by a net profit margin of 28.4% and a return on equity of 17.4%. These results underpin the ongoing demand for its robotic surgical systems and hospital equipment globally.

Dividend

Intuitive Surgical does not pay a dividend, retaining its earnings to fund research, development, and expansion of its minimally invasive care technologies.

Insider Buying and Selling at Intuitive Surgical, Inc.

Company insiders executed several sales in late summer. Officer Mark Preston Brosius sold 154 shares on August 21, 2026, for $59,439.00; 69 shares on September 9, 2026, for $24,671.00; and 48 shares on September 11, 2026, for $17,141.00. Additionally, officer Fredrik Widman sold 1,089 shares at $374.44 per share on September 15, 2026, for a total value of $407,765.00.

About Intuitive Surgical, Inc.

Headquartered in Sunnyvale, California, Intuitive Surgical develops and markets advanced tools that help doctors perform minimally invasive procedures. Its flagship technology assists surgeons in hospitals worldwide, driving steady demand across the healthcare sector.

Bottom Line

Barclays's updated price target reflects confidence in the company's growth trajectory despite recent share price movements. Investors will monitor upcoming financial reports and institutional filing updates for further signs of sector momentum.

Source: Barclays's rating change on $ISRG (Oct 21, 2026). Written by software, not financial advice. How we make alerts

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