Leerink Partners Raises ISRG Price Target to $503

Intuitive Surgical, Inc. (ISRG) business photo

Key Points

  • Leerink Partners maintained its Outperform rating on Intuitive Surgical, Inc. on October 21, 2026, lifting its target price from $473.00 to $503.00.
  • Leerink Partners's $503 price target implies 17.51% upside from Intuitive Surgical, Inc.'s ($ISRG) current $428.05 share price.
  • The medical device maker recently posted trailing-twelve-month revenue of $11.03 billion alongside earnings of $8.85 per share.
  • Wall Street maintains a general buy consensus on the stock, backed by 30 analyst opinions and a mean price target of $478.53.

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On October 21, 2026, Leerink Partners maintained its Outperform rating on Intuitive Surgical, Inc. (NasdaqGS: ISRG) while boosting its price target from $473.00 to $503.00. The research note outlines the firm's forward-looking view on the medical equipment maker as shares closed at $430.46 on the day of the announcement. Stock exchange data shows the company recently traded around $427.48.

ISRG Intuitive Surgical, Inc.
$428.12 -23.82% year to date
Daily close · Oct 21, 2026
Analyst rating track record

Leerink Partners vs. the S&P 500

YTD return -8.12% hypothetical
All-time return -8.12% S&P 500 +3.07%
vs. S&P 500 -11.19% behind the index

Hypothetical returns from Leerink Partners's disclosed trades, not real profit or advice. How we model this.

Leerink Partners' Call on Intuitive Surgical

In its October 21, 2026 research note, Leerink Partners kept an Outperform rating on Intuitive Surgical, Inc. and raised its target from $473.00 to $503.00. The firm's target reflects its updated expectations for the healthcare provider.

Other Institutional Activity in Intuitive Surgical

Other large funds have adjusted their holdings in the medical device maker recently. Davenport reduced its holdings by 145,132 shares, ending with 8,095 shares valued at about $3,291,545 on October 14, 2026. Meanwhile, Assenagon Asset Management S.A. grew its stake by 558,099 shares, finishing with 1,557,940 shares worth roughly $633,505,142 on October 15, 2026.

Intuitive Surgical, Inc. Stock Up 0.3%

Intuitive Surgical, Inc. shares recently traded around $427.48, down about 0.7% from the event-day close of $430.46 on October 21, 2026. The stock sits above its 50-day moving average and below its 200-day moving average.

12-month forecast

$ISRG price target

Intuitive Surgical, Inc. daily closes and this analyst's $503 target. Not advice.

Recent Earnings

Intuitive Surgical reported trailing-twelve-month revenue of $11,034,399,744 and earnings of $8.85 per share. The company generated a net profit margin of 28.4% and a return on equity of 17.4% over the period, supported by year-over-year revenue growth of 18.5%.

Insider Buying and Selling at Intuitive Surgical, Inc.

Company insiders have made several share dispositions recently. Officer Mark Preston Brosius disposed of 154 shares valued at $59,439 on August 21, 2026, followed by 69 shares worth $24,671 on September 9, 2026, and 48 shares worth $17,141 on September 11, 2026. Additionally, officer Fredrik Widman disposed of 1,089 shares at a price of $374.44 per share for a total value of $407,765 on September 15, 2026.

Analysts Set New Price Targets

Several other firms issued updates alongside Leerink Partners on October 21, 2026. JP Morgan maintained its Overweight rating and lifted its target to $475.00 from $450.00. Evercore ISI Group maintained an In-Line rating while lowering its target from $400.00 to $385.00. Wells Fargo maintained an Overweight rating and moved its target slightly from $487.00 to $486.00. TD Cowen reiterated a Buy rating with an unchanged target of $485.00. Overall, the stock holds a buy consensus recommendation across 30 analyst opinions.

About Intuitive Surgical

Headquartered in Sunnyvale, California, Intuitive Surgical, Inc. creates robotic systems and tools that help doctors perform minimally invasive surgeries. The company operates globally, providing medical technology designed to improve patient care access and clinical outcomes. Its flagship products support surgeons across various medical specialties.

Bottom Line

Leerink Partners joins a group of major financial institutions adjusting targets for Intuitive Surgical, Inc. Investors continue to monitor analyst updates and institutional filings as the healthcare sector evolves. No investment stance is implied by these research notes.

Source: Leerink Partners's rating change on $ISRG (Oct 21, 2026). Written by software, not financial advice. How we make alerts

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